منابع مشابه
Latent mutants in chemostats.
HE correlation of spontaneous mutation with active growth in cell culture Thas led in the past to a common tacit assumption that division is required for mutation, an assumption exposed by the expression of mutation rates as some function of division. A ready explanation was provided by the error (copy-error) hypothesis which views mutation as an error in gene duplication, and which predicts th...
متن کاملMichael Malisoff’s Research on Chemostats
Chemostat models provide the foundation for much current research in bioengineering, ecology, and population biology [8]. In engineering, the chemostat is known as the continuous-stirred tank reactor. It is used to model the dynamics of interacting organisms in waste-water treatment plants, lakes and oceans, and in biomedical contexts. The basic mathematical model of the chemostat is a system o...
متن کاملBacterial growth and adaptation in microdroplet chemostats.
We describe herein microfluidic technology for manipulating and monitoring continuous growth of populations of bacteria. A system consisting of approximately ten input and output channels controls more than 100 microdroplet chemostats and enables the manipulation of chemical factors in each microchemostat independently over time. Herein, we characterize the dynamics of bacterial populations in ...
متن کاملChemostats with random inputs and wall growth
Chemostat refers to a laboratory device used for growing microorganisms in a cultured environment, and has been regarded as an idealization of nature to study competition modeling of mathematical biology. The simple form of chemostat model assumes that the availability of nutrient and its supply rate are both fixed. In addition the tendency of microorganism to adhere to surfaces is neglected by...
متن کاملLatent Effects of Hsp90 Mutants Revealed at Reduced Expression Levels
In natural systems, selection acts on both protein sequence and expression level, but it is unclear how selection integrates over these two dimensions. We recently developed the EMPIRIC approach to systematically determine the fitness effects of all possible point mutants for important regions of essential genes in yeast. Here, we systematically investigated the fitness effects of point mutatio...
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ژورنال
عنوان ژورنال: Genetics
سال: 1961
ISSN: 1943-2631
DOI: 10.1093/genetics/46.2.105